Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
Top Medical Research Studies
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Most Useful Reviews
9
Supports nervous system
3 people found this helpful
P-5-P is an excellent form of vitamin B6 that provides superb support for the nervous system. This formulation offers a superior bioavailability and aids in combating nervous exhaustion. Our attending physician prescribed it for a severe cold alongside other medications. I ordered two packs at once and noticed marked improvements in my well-being, with no signs of depression and a revitalised nervous system.
7.5
Better vitamin absorption
3 people found this helpful
I have a metabolic disorder called HPU, which has resulted in a long-standing deficiency of B vitamins, particularly B6. I have discovered that I best absorb products containing the active form of the ingredient, which is P5P. The sizeable pack with 90 capsules allowed me to take 2 to 4 daily for effects. My deficiency has now been compensated, and my nervous system functions much better, complemented by a high-quality vitamin B complex.
7.5
Feeling much better
2 people found this helpful
I was diagnosed with a severe genetic metabolic disorder. My doctor stated that this supplement is crucial for me. I began with a small dose and have gradually increased to two capsules per day. While it can still make me quite tired for a few hours, I overall feel much better.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
7
We explored how vitamin B-6 status affects individuals with rheumatoid arthritis (RA) undergoing treatment with TNFα inhibitors. In our study, we looked at 106 RA patients, tracking their vitamin B-6 levels before and after three months of treatment. We measured key markers like pyridoxal 5'-phosphate, along with 3-hydroxykynurenine and xanthurenic acid, to assess participants' vitamin B-6 status.
What we found was quite interesting. Our results showed that both vitamin B-6 markers were linked to disease activity in RA patients. Specifically, changes in the ratio of 3-hydroxykynurenine to xanthurenic acid correlated with how active the disease was. This suggests that vitamin B-6 could play a role in inflammation and disease progression in RA.
However, while we highlighted an association, it's important to remember that this does not directly imply a therapeutic effect of vitamin B-6 in treatment for autoimmune disorders. More research is needed to determine if any direct benefits exist, especially considering other treatments being administered.
What we found was quite interesting. Our results showed that both vitamin B-6 markers were linked to disease activity in RA patients. Specifically, changes in the ratio of 3-hydroxykynurenine to xanthurenic acid correlated with how active the disease was. This suggests that vitamin B-6 could play a role in inflammation and disease progression in RA.
However, while we highlighted an association, it's important to remember that this does not directly imply a therapeutic effect of vitamin B-6 in treatment for autoimmune disorders. More research is needed to determine if any direct benefits exist, especially considering other treatments being administered.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports nervous system
3 people found this helpful
P-5-P is an excellent form of vitamin B6 that provides superb support for the nervous system. This formulation offers a superior bioavailability and aids in combating nervous exhaustion. Our attending physician prescribed it for a severe cold alongside other medications. I ordered two packs at once and noticed marked improvements in my well-being, with no signs of depression and a revitalised nervous system.
7.5
Better vitamin absorption
3 people found this helpful
I have a metabolic disorder called HPU, which has resulted in a long-standing deficiency of B vitamins, particularly B6. I have discovered that I best absorb products containing the active form of the ingredient, which is P5P. The sizeable pack with 90 capsules allowed me to take 2 to 4 daily for effects. My deficiency has now been compensated, and my nervous system functions much better, complemented by a high-quality vitamin B complex.
7.5
Feeling much better
2 people found this helpful
I was diagnosed with a severe genetic metabolic disorder. My doctor stated that this supplement is crucial for me. I began with a small dose and have gradually increased to two capsules per day. While it can still make me quite tired for a few hours, I overall feel much better.
9
Best healing effect
2 people found this helpful
Only the active form of B6 (P5P) has had the best healing effect on my conditions such as ADHD, obsessive-compulsive disorder, and tic disorder. It's been essential for my overall health management.
6
Normalised sleep achieved
2 people found this helpful
This excellent B6 in a highly digestible form helped me normalise my sleep. I took it alongside magnesium, as magnesium cannot be absorbed without B6. The dosage is fantastic, and I experienced no side effects.
Frequently Asked Questions
9
Supports nervous system
3 people found this helpful
P-5-P is an excellent form of vitamin B6 that provides superb support for the nervous system. This formulation offers a superior bioavailability and aids in combating nervous exhaustion. Our attending physician prescribed it for a severe cold alongside other medications. I ordered two packs at once and noticed marked improvements in my well-being, with no signs of depression and a revitalised nervous system.
7.5
Better vitamin absorption
3 people found this helpful
I have a metabolic disorder called HPU, which has resulted in a long-standing deficiency of B vitamins, particularly B6. I have discovered that I best absorb products containing the active form of the ingredient, which is P5P. The sizeable pack with 90 capsules allowed me to take 2 to 4 daily for effects. My deficiency has now been compensated, and my nervous system functions much better, complemented by a high-quality vitamin B complex.
7.5
Feeling much better
2 people found this helpful
I was diagnosed with a severe genetic metabolic disorder. My doctor stated that this supplement is crucial for me. I began with a small dose and have gradually increased to two capsules per day. While it can still make me quite tired for a few hours, I overall feel much better.
9
Best healing effect
2 people found this helpful
Only the active form of B6 (P5P) has had the best healing effect on my conditions such as ADHD, obsessive-compulsive disorder, and tic disorder. It's been essential for my overall health management.
6
Normalised sleep achieved
2 people found this helpful
This excellent B6 in a highly digestible form helped me normalise my sleep. I took it alongside magnesium, as magnesium cannot be absorbed without B6. The dosage is fantastic, and I experienced no side effects.
7.5
Recommended for dermatitis
1 people found this helpful
I purchased this on my immunologist's recommendation for my teenager with allergic conditions. It has significantly helped in the complex treatment of atopic dermatitis when used together with TMG. I wholeheartedly recommend this product.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
7
We explored how vitamin B-6 status affects individuals with rheumatoid arthritis (RA) undergoing treatment with TNFα inhibitors. In our study, we looked at 106 RA patients, tracking their vitamin B-6 levels before and after three months of treatment. We measured key markers like pyridoxal 5'-phosphate, along with 3-hydroxykynurenine and xanthurenic acid, to assess participants' vitamin B-6 status.
What we found was quite interesting. Our results showed that both vitamin B-6 markers were linked to disease activity in RA patients. Specifically, changes in the ratio of 3-hydroxykynurenine to xanthurenic acid correlated with how active the disease was. This suggests that vitamin B-6 could play a role in inflammation and disease progression in RA.
However, while we highlighted an association, it's important to remember that this does not directly imply a therapeutic effect of vitamin B-6 in treatment for autoimmune disorders. More research is needed to determine if any direct benefits exist, especially considering other treatments being administered.
What we found was quite interesting. Our results showed that both vitamin B-6 markers were linked to disease activity in RA patients. Specifically, changes in the ratio of 3-hydroxykynurenine to xanthurenic acid correlated with how active the disease was. This suggests that vitamin B-6 could play a role in inflammation and disease progression in RA.
However, while we highlighted an association, it's important to remember that this does not directly imply a therapeutic effect of vitamin B-6 in treatment for autoimmune disorders. More research is needed to determine if any direct benefits exist, especially considering other treatments being administered.
9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
References
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. doi:10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. doi:10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. doi:10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. doi:10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. doi:10.1111/j.1756-185X.2011.01679.x
